Databases and Search Engines
ClinicalTrials.gov is a registry of federally and privately supported
clinical trials conducted in the United States and around the world.
ClinicalTrials.gov gives you information about a trial's purpose, who may
participate, locations, and phone numbers for more details. This information
should be used in conjunction with advice from health care professionals.
Since 1991, the Community Research Initiative on AIDS's (CRIA) Drug Trials
program has partnered with prominent researchers, physicians, and
community-based clinics across the U.S. in pursuit of the newest and most
promising therapies and treatments for HIV and related illnesses. More
than a dozen of the drugs tested through CRIA have received FDA
approval, and we have undertaken groundbreaking independent research in the
areas of antiretroviral side effects management. Through our efforts,
people living with HIV and AIDS are receiving the newest and best treatments
for thrush, lipodystrophy, treatment-related diarrhea, and a host of other
ailments, living longer and healthier lives.
The Sandbar Digital Library is a federally funded research project that
combined the findings from 114 qualitative studies, in which women were
interviewed about different aspects of being an HIV-positive woman. The 2 main
subjects women talked about in these studies were motherhood and stigma. The
digital library provides summaries of these studies, and is intended to be
useful for HIV-positive women, clinicians, and researchers.
Clinical Trial Networks
The HIV Prevention Trials Network (HPTN), a worldwide collaborative clinical
trials network, develops and tests the safety and efficacy of primarily
non-vaccine interventions designed to prevent the transmission of
HIV. HPTN research studies emerge from the six scientific working groups
and are developed by protocol teams that include HPTU (HIV Prevention Trials
Units) investigators and recognized experts in HIV prevention. As study
protocols are developed they undergo a rigorous intra- and extra-network review
process that ensures compliance with current ethical guidelines and regulatory
The International Maternal Pediatric Adolescent AIDS Clinical Trials
(IMPAACT) group is a new Leadership Group representing a merger of
investigators from the Pediatric AIDS Clinical Trials Group (PACTG) and the
Perinatal Scientific Working Group of the HIV Prevention Trials Network
(HPTN/HIVNET). The mission of the IMPAACT group, which is worldwide in scope,
is to significantly decrease the mortality and morbidity associated with HIV
disease in pregnant women, children, and adolescents. An Excel spreadsheet
of all on-going (transition) and Proposed IMPAACT research trials, including
information about enrollments and anticipated opening dates, can be accessed
from the IMPAACT Web site.
The Adult AIDS Clinical Trials Group (AACTG), the largest HIV clinical
trials organization in the world, is a network of 38 university-based research
sites. The goal of the AACTG is to assist in defining the standards of
care of HIV-infected persons. Search this interface by Trial Category.
Interagency HIV Study (WIHS)
The Women's Interagency HIV Study (WIHS) was established in August of 1993
to investigate the impact of HIV infection on women in the U.S. The core
portion of the study includes a detailed and structured interview, physical and
gynecologic examinations, and laboratory testing. The WIHS participants are
also asked to enroll in various sub-studies, such as cardiovascular, metabolic,
physical functioning, and neurocognition. New proposals for WIHS sub-studies
are submitted for approval by various scientific investigators from around the
world. For more information on the WIHS cohort, please click
Community Programs for Clinical Research on AIDS (CPCRA) is a clinical
trials group that conducts research through a national network of
community-based clinical units. CPCRA strives to reach underserved populations
by conducting trials in primary care settings. CPCRA’s trials focus on the day
to day medical management of HIV disease. The Web site provides a detailed list
of publications and presentations.
There are twenty-one Centers for AIDS Research (CFAR). This link provides
contact information for directors & administrators and a link to individual
center’s Web sites if available.
Journal Search Engines
PubMed includes Medline and OldMedline, which collectively represent 14
million journal citations in the field of medicine and allied health sciences
dating back to 1950. Provides a summary of journal articles, citations, and
when available, a link to full-text Web sites.
Showcases journals, papers, and abstracts on various HIV-related topics.
‘New & Noteworthy’ section lists recently published journal articles
in several categories, including: Disease Management Update, Drug Update,
Diagnostic Update, Marginalized Update, US Health Update, Global Update, and
Week In Review (most frequently accessed reports during the previous week).