HIV Treatment Guidelines for Pregnant People and Their Infants

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What Are HIV Treatment Guidelines?

HIV treatment guidelines provide a lot of useful information to help healthcare providers and people living with HIV make decisions about numerous HIV-related health concerns. These include when – and with which medications – to start, stop, or change HIV treatment. There are specific guidelines for people living with HIV who are pregnant or have given birth, which also offer guidance on how to feed their infants.

The perinatal HIV clinical guidelines are prepared by a group of physicians and other professionals with special expertise in HIV treatment and prevention during pre-pregnancy, pregnancy, and the perinatal and newborn periods.

US-Based Guidelines

A branch of the US government called the Department of Health and Human Services (DHHS) has put together a set of HIV treatment guidelines. The US DHHS provides several different treatment guidelines related to HIV care, including:

Most of the information in this fact sheet is to provide an overview of the perinatal HIV clinical guidelines. See our fact sheet on HIV Treatment Guidelines for more information on the adult and adolescent HIV treatment guidelines. For information on caring for children living with HIV, see our fact sheet on Care and Treatment for Children Living with HIV. See also our fact sheet on Pregnancy, Birth, and HIV for more information on having biological children while living with HIV.

All of the DHHS HIV guidelines are written and reviewed regularly by a group of HIV experts, including researchers, healthcare providers, and community activists. They have been updated many times as new information and new medications become available. The full version of the perinatal HIV clinical guidelines is available here.

Global Guidelines

HIV treatment guidelines can vary based on where you live in the world. Like the US, many countries and regions have their own HIV treatment guidelines based on circumstances in that area of the world, including availability of different HIV drugs and other resources. The World Health Organization (WHO), a massive agency which leads public health efforts worldwide, produces global guidance on HIV testing, treatment, prevention, care, and services – including during the perinatal period.

All internationally written guidelines are in agreement about certain aspects of HIV treatment. For instance, since 2015, the DHHS, WHO, EACS (European AIDS Clinical Society), BHIVA (British HIV Association), and the IAS-USA (International Antiviral Society-USA) have all recommended that HIV treatment be offered to all people living with HIV, regardless of their CD4 cell count. Research has shown that people living with HIV who start treatment earlier, while their CD4 counts are still high, have a much lower risk of illness and death.

HIV treatment guidelines can vary based on where you live in the world.

However, HIV guidelines can differ between regions on many other details. Infant feeding while living with HIV is one example. The WHO recommends that women living with HIV breastfeed their infants if they are taking HIV drugs and live in an area of the world where formula feeding may not be a safe option. Studies of women living with HIV and their infants in resource-limited areas like sub-Saharan Africa and India have shown that the likelihood of transmitting HIV while breastfeeding can be as low as less than 1 percent if the birthing parent is taking effective HIV drugs.

On the other hand, birthing parents living with HIV in so-called high-resource regions, such as the US or Europe, are most often told not to breastfeed their babies. The DHHS, EACS, and BHIVA guidelines all recommend that women living with HIV avoid breastfeeding since infant formula, clean water to mix it, and refrigeration to store it tend to be readily available in these areas (though that is not always the case). These guidelines are based on the belief that even extremely low risk of a baby getting HIV from breast milk is not justified when alternatives are available.

However, parents may also want to consider breast/chestfeeding for important emotional, cultural, family, and health reasons, even if they live in an area where formula is easily accessible. In recent years, the DHHS, BHIVA, and EACS HIV treatment guidelines have included updates that acknowledge the desire of some women living with HIV in resource-rich countries to breastfeed. While not a recommendation, these updates suggest ways for providers to support the health of women and other parents living with HIV who may choose to breast/chestfeed, as well as the health of their babies. BHIVA's guidelines stress informed decision-making and support for parents considering breastfeeding. In the US, the perinatal HIV clinical guidelines take a similar approach.

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Key Information in the March 2022 US DHHS Perinatal HIV Clinical Guidelines

The guidelines for pregnant people had their last major update in December 2021, with a minor update in March 2022. Below is a summary of recommendations from the current perinatal HIV clinical guidelines. Additional updates to these guidelines are expected later in 2022.

Preventing HIV Acquisition in the Pregnant Person with Pre-Exposure Prophylaxis (PrEP)

HIV-negative people who may become pregnant, as well as people who are breast/chestfeeding, should be offered pre-exposure prophylaxis (PrEP) if they ask for it or express that they may be vulnerable to HIV. Providers should also have a conversation about PrEP with people for whom one or more of the following factors are true:

People who are HIV-negative, and have a partner living with HIV who is taking HIV drugs and has an undetectable viral load (not enough HIV in the blood for tests to measure), do not need to take PrEP because their partner cannot transmit the virus sexually. See our fact sheet on Undetectable Equals Untransmittable (U=U) for more information.

Only daily oral (by mouth) Truvada (tenofovir disoproxil fumarate/emtricitabine) is recommended for PrEP in HIV-negative people who want to become or are pregnant. This is because it is unclear whether other biomedical HIV prevention options, such as the dapivirine vaginal ring or injectable long-acting cabotegravir, are safe before or during pregnancy, or while breast/chestfeeding. Oral Descovy (tenofovir alafenamide/emtricitabine) has not been approved for PrEP in people with a vagina who have sex with people with a penis (usually cisgender heterosexual women).

Caring for People Living With HIV Who May Become Pregnant

Healthcare providers are advised to ask all people living with HIV who might become pregnant whether they plan to have a biological child. If they do not, they may have a conversation about effective contraception, including potential interactions between certain HIV drugs and hormonal contraception (“the pill”). For more information, see our fact sheet on Contraception and HIV.

Healthcare providers are advised to ask all people living with HIV who might become pregnant whether they plan to have a biological child.

It is a good idea for people living with HIV who may become pregnant to get their viral load down to undetectable before trying to conceive a child. The person’s current HIV drug regimen should also be discussed since some HIV drugs are not recommended for use before or during pregnancy or breastfeeding. As with all medical decisions, the healthcare provider and patient should jointly decide on the best plan.

All people who want to become pregnant are advised to reduce or stop drinking alcohol, smoking tobacco, or taking street drugs, including marijuana. The perinatal HIV clinical guidelines recommend the same counseling for people living with HIV.

Getting Pregnant When One Partner Lives With HIV

If the non-birthing partner is living with HIV, taking HIV drugs, and their viral load is undetectable, they cannot transmit the virus to their partner. To be extra-sure, the HIV-negative partner can take PrEP (see section above) while having condomless sex in order to conceive a child.

PrEP for the HIV-negative partner is also an option if the viral load of the partner living with HIV is unknown or is detectable. Limiting condomless sex to times when the person trying to get pregnant is ovulating (at their most fertile) can further reduce the possibility of HIV transmission.

If the partner who is trying to become pregnant is living with HIV, it is a good idea for them to get their own viral load down to undetectable before trying to conceive. This helps to prevent HIV being passed on to their partner during condomless sex in order to conceive a child – and will reduce the chance of perinatal transmission.

For more information on conceiving a child when one or both partners are living with HIV, see our fact sheet on Getting Pregnant and HIV.

HIV Drugs During Pregnancy

People who are already taking HIV drugs and are virally suppressed (very low levels of virus in the body) before becoming pregnant are generally advised to continue taking the same medications. In some cases, the dosage (amount of drug) may need to be adjusted, or different drugs might be considered, because the levels of certain HIV drugs fall too low as a result of changes in a pregnant person’s body. A person’s HIV drug regimen (combination of drugs) may need to be changed in certain specific cases. Providers are encouraged to discuss the current HIV regimen with a pregnant person, and both should decide together whether to change drugs and what to change them to.

People who are already taking HIV drugs and are virally suppressed before becoming pregnant are generally advised to continue taking the same medications.

For people who have not taken HIV drugs before becoming pregnant (called “antiretroviral-naive”), or who have taken HIV drugs before but are not taking them when they get pregnant, it is important to start treatment as soon as possible. This may mean starting HIV drugs before the results of drug resistance testing are available, and changing drugs later, if necessary. The guidelines list certain combinations as preferred for antiretroviral-naive pregnant people. However, the pregnant person and their provider may decide that a different drug combination works better in a specific situation.

Our HIV Drug Chart includes information on what is known about specific drugs during pregnancy and breastfeeding. In many cases, little information is available because pregnant people are often not included in clinical trials for medications, including for HIV drugs.

Infant Feeding and HIV

Some people who are living with HIV in the US, Canada, and Europe do breastfeed their infants. As discussed above, guidelines in several regions, including the US, have been updated to recognize this fact. The US perinatal HIV clinical guidelines advise that healthcare providers inform and support the decisions of parents living with HIV on how to feed their babies, without judgment – though the general US HIV guidelines still have not changed their recommendation that people living with HIV do not breastfeed.

A database in Great Britain has so far recorded 90 babies born to people living with HIV who were breastfed. None of the infants acquired HIV. A growing number of studies are showing that infants are remaining HIV-negative during breast/chestfeeding when the lactating parent is on HIV treatment and has an undetectable viral load.

A growing number of studies are showing that infants are remaining HIV-negative during breast/chestfeeding when the lactating parent is on HIV treatment and has an undetectable viral load.

The recommendation not to breastfeed also assumes that everyone has access to safe water and sufficient formula. Recent events, such as the polluted water supply in the US city of Flint, Michigan, and a shortage of formula due to the temporary closure of a factory, have shown that this is not always the case even in high-resource countries, such as the US.

Our fact sheet Can I Breastfeed While Living With HIV? An Overview of Infant Feeding Options has more information on this topic.

Caring for the Newborn

Infants born to people living with HIV are recommended to receive HIV drugs to prevent them from acquiring HIV. The specific drugs and how long they should be given depend on the birthing parent’s HIV treatment status and viral load, as well as whether the infant is breast/chestfed.

Infants born to people living with HIV are recommended to receive HIV drugs to prevent them from acquiring HIV.

If the parent was taking HIV drugs during pregnancy, continues to take them as prescribed, and was virally suppressed at least four weeks before giving birth, the infant should be given zidovudine for four weeks after birth. If the parent was not taking HIV drugs during pregnancy, was not virally suppressed four weeks before delivery, or has primary/acute HIV (acquired HIV in the past several months), the infant should be treated with multiple HIV medications for two to six weeks to prevent them from acquiring HIV. If the parent has primary/acute HIV during breastfeeding, the infant should also be treated to prevent them from acquiring HIV.

Only certain HIV drugs are recommended for very young children, and the recommendations are different for infants born very prematurely (before 32 weeks after the parent’s last menstrual period). Healthcare providers in the US can call the National Perinatal HIV Hotline at (888) 448-8765, 24 hours a day, seven days a week, to get help in making treatment decisions in specific cases.

Other Information

The perinatal HIV clinical guidelines also include information on procedures to avoid during delivery, caring for people who do not know their HIV status when they are going into labor, and many other issues. A new section also talks about pregnancy in transgender and gender-diverse people. In general, the same recommendations for HIV prevention, testing, and treatment apply as for cisgender pregnant people, but hormones taken for transitioning may need to be addressed in the context of pregnancy. These guidelines emphasize the need for gender-affirming shared decision-making between provider and patient.

Taking Care of Yourself

The perinatal HIV clinical guidelines are a set of recommendations to help you and your healthcare provider understand your treatment choices. They are based on the most up-to-date information from studies and clinical trials. But remember, they are only general suggestions. It is okay for you and your healthcare provider to choose therapies and approaches for your specific situation. Use the guidelines as a resource to help you and your provider make well-informed health decisions that are right for you and your family.

Special thanks to Lealah Pollock, MD, MS, of the University of California – San Francisco, for her review of this fact sheet.

Additional Resources

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