Vitamins and Supplements

Submitted on Apr 28, 2023

Vitamins spilling out of a bottle and vegetables.

Table of Contents

Micronutrients and HIV

Vitamins, minerals, and antioxidants are called micronutrients. Even though the body only needs small amounts, micronutrients are essential for good health. They are used for different chemical reactions in and between our cells as part of the body's normal functions. While some people get the nutrients they need from a healthy, balanced diet, many people living with HIV need more micronutrients than they can get from their diet to support the immune system and help heal cells damaged by the virus. Several studies have shown that taking micronutrient supplements can help keep people living with HIV healthier longer.

[E]ven in resource-rich areas, it is possible to eat well, feel fine, and still not get enough of certain vitamins, minerals, and antioxidants.


Vitamins generally fall into one of two categories: (1) fat-soluble, or those that dissolve in fats, and (2) water-soluble, or those that dissolve in water.

When you take in fat-soluble vitamins (through foods or supplements), your body uses what it needs and stores the rest. Fat-soluble vitamins include vitamins A, D, E, and K. It is important not to take too much of these vitamins because they can build up in the body and cause harmful side effects. For example, too much vitamin A (beta-carotene) can cause nausea, blurred vision, birth defects, and liver problems.

When you take in water-soluble vitamins, such as B vitamins and vitamin C, your body uses what it needs and filters out the extra vitamins into your urine ("pee"). Side effects from water-soluble vitamins are less common but can occur. For example, large doses of vitamin C can cause nausea, stomach cramps, and diarrhea.


Minerals form the structures in the body (calcium in bone, iron in blood) and play a role in the normal functioning of nerves, muscles, and hormones. Several minerals, including zinc, selenium, and iron, have a role in fighting HIV. Calcium is especially important for women during the time around menopause (perimenopause) and after menopause.


The body produces molecules called free radicals as part of its normal functioning. Free radicals can damage your body's cells. Certain factors, such as infection, pollution, and cigarette smoke, can increase the number of free radicals in the body. Antioxidants can keep the extra free radicals from causing damage. Some vitamins, including vitamins A, C and E, are antioxidants. Selenium is also an antioxidant.

Getting Enough Micronutrients

While micronutrients can be found in food, some people living with HIV cannot get all the nutrients they need through their diet. There are a number of reasons: because of HIV itself, changes in metabolism (the way your body uses food), poor appetite, diarrhea, poor absorption of nutrients, or HIV-related conditions such as HIV wasting and AIDS.

While some people get the nutrients they need from a healthy, balanced diet, many people living with HIV need more micronutrients than they can get from their diet to support the immune system and help heal cells damaged by the virus.

Micronutrients that are often low in people living with HIV include vitamin A, vitamin D, vitamin E, selenium, zinc, and B complex vitamins (B1, Thiamine; B2, Riboflavin; B3, niacin; B6, Pyridoxine; B12, Cobalamin; and B9, folic acid). Some research shows that low levels of these vitamins can lead to lower CD4 cell counts and worsening of HIV. They can also cause other problems, such as diarrhea, neuropathy, and skin conditions.

In resource-poor areas, many women do not get enough micronutrients because they do not have access to enough food or good-quality food. Yet even in resource-rich areas, it is possible to eat well, feel fine, and still not get enough of certain vitamins, minerals, and antioxidants.

The Recommended Dietary Allowance (RDA) for each nutrient is set by the US government as a guideline on the amount of daily nutrients needed to maintain good physical health. Half of all women in the US do not get even the basic RDA requirements for folic acid, iron, zinc, calcium, magnesium, copper, vitamins A, D, E, and certain B vitamins from food due to dieting for weight loss, eating unhealthy foods, lack of time, or other pressures. This puts women, especially women living with HIV, at special risk for low levels of micronutrients. In addition, women often need more nutrients because of menstruation, pregnancy, or menopause.

Eating a well-balanced diet should be the basis of any plan to correct micronutrient deficiencies (not enough vitamins and minerals). Since different vitamins and minerals are found in different food groups, it is important to include foods from each group in your diet every day. (Read more about food groups at the US Department of Agriculture's "MyPlate" website.)

  • Protein group – Healthy foods from this group include lean red meats, skinless chicken or turkey, fish, nuts, peanut butter, soy products, seeds, beans, quinoa, and peas
  • Grains group – Healthy foods from this group include whole grain breads, whole grains such as oats and wheat, oatmeal, and brown rice
  • Fruit group – Any fresh fruit is a good choice
  • Vegetable group – Fresh and frozen vegetables are the best
  • Dairy group – Try to choose one percent or skim (non-fat) milk, low-fat yogurt and cottage cheese, and small amounts of cheese

For more information, see our fact sheet on Nutrition and HIV.

Taking Supplements

It is important to get as many of the vitamins and minerals you need as possible from food. Nutrients found in food are better for your body than nutrients found in supplements. While supplements do not replace a well-balanced diet, they can help you get the additional micronutrients you need. Supplements include vitamins, minerals, herbs, and other related products used to boost the amount of nutrients in your diet. Supplements are available in pill, capsule, tablet, powder, or liquid form.

Speak to your health care provider and see a registered dietician for a nutritional evaluation. They can help you determine what combination of diet changes and supplements you need.

Here are some basic recommendations:

  • Take a multivitamin/multimineral supplement (without extra iron) every day
  • Multivitamins should be taken with food and a full glass of water to help your body absorb (soak up) the vitamins and prevent stomach upset
  • Consider a B complex vitamin and an antioxidant supplement in addition to your multivitamin. If you are a vegetarian or a vegan, consider getting your vitamin B12 level checked; if it is low, ask your provider for the correct amount of B12 to take.
  • Because women are at higher risk for bone disease, make sure you are getting 1,000 milligrams of calcium (1,200 milligrams if you are over 50) from food or supplements each day. If you are a vegan, you may need to be extra careful about getting enough calcium. Women who are menopausal (no longer have menstrual periods) do not have the estrogen levels to support new bone growth.
  • Humans make vitamin D by exposing our skin to the sun. Many people are low in vitamin D, which is important for absorbing and using calcium. It is important to have your vitamin D level checked and to ask your provider for the correct amount of vitamin D to take if your level is low. The RDA for vitamin D is 600 units (or 15 micrograms) per day.
  • Iron may be too low in women, especially during their menstrual periods. This can lead to anemia. However, people living with HIV should not take extra iron without talking to their health care provider.
  • Because studies have shown that St. John's Wort (Hypericum perforatum) affects the levels of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in the blood, people taking any HIV drugs should not take St. John's Wort. St. John's Wort is an herb commonly used against depression.
  • If you are planning to get pregnant, speak to your health care provider about prescription pregnancy vitamins that contain folic acid. Folic acid needs to be taken before becoming pregnant, since that vitamin is most important during the first six to eight weeks of pregnancy to protect the developing baby’s nervous system.
  • It is also important to know that certain minerals can inhibit (slow or prevent) HIV drugs called integrase inhibitors from being absorbed (taken up) by your body. These minerals include iron and calcium, as well as multivitamins that contain them. These supplements should be taken either two hours before the integrase inhibitor, or six hours after).

While few of these supplements have been studied in people living with HIV, you may want to consider:

  • Alpha-lipoic acid: for its antioxidant properties and as a treatment for diabetic neuropathy. Suggested dose: 20-50 mg per day for general antioxidant properties, 200-300 mg per day for diabetic neuropathy. Reportedly tolerated well up to 600 mg per day.
  • Carnitine (also called acetyl-L-carnitine): to support proper metabolism. It may also help with neuropathy. Suggested dose: 500 mg to 3000 mg (3 g) per day.
  • Coenzyme Q10: acts as an antioxidant and supports immune function. Suggested dose: 30-200 mg per day.
  • Cysteine (also called N-acetyl-L-cysteine, or NAC): the body converts cysteine to glutathione, a powerful antioxidant. Suggested dose of NAC: 500 mg per day to start; people living with HIV may take up to 4,000 mg per day, under your health care provider's supervision.
  • Probiotic supplements: these contain "healthy bacteria" such as acidophilus to support digestion and immune health. They are found naturally in yoghurt, fermented fruits and vegetables and kombucha, but can also be taken as supplements. Having healthy bacteria in your gut helps your body absorb more nutrients and make the most of what you eat. A suggested dose of Lactobacillus acidophilus (L. acidophilus), one of the most common probiotics, is one to two billion colony-forming units (CFUs). The dose depends on the health condition that is treated. Those using probiotics may take as many as 15 billion CFUs per day for intestinal health under their health care provider's supervision.
  • Omega-3 fatty acids: these are found naturally in fish, nuts, seeds, and vegetable oils, but can also be taken as supplements. Research among people living with HIV has shown that taking omega-3 fatty acid supplements was associated with lower levels of triglycerides (which can cause heart disease) and a marker for inflammation.

Because of the potential for side effects and interactions with medications, supplements should be taken only under the supervision of a knowledgeable health care provider.

Deciding which supplements to take can be difficult and confusing because there are so many different kinds on the market. Try not to choose based on price, fancy or expensive packaging, or product promises. Instead, read the label to see what is really inside.

Micronutrients are essential to your body's healthy functioning. However, making sure you get enough nutrients without taking too much can be tricky. Speak to your health care provider or a dietician who knows about HIV about the supplements you should or are planning to take and possible side effects or interactions with your HIV drugs.



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